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Associations between chronic pelvic pain and psychiatric disorders and symptoms

Ana Carolina Franco de Carvalho1, Omero Benedito Poli-Neto1,
José Alexandre de Souza Crippa1,2, Jaime Eduardo Cecílio Hallak1,2, Flávia de Lima Osório1,2

1 Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

2 INCT Translational Medicine, National Council for Scientific and Technological Development (CNPq), Brasília, DF, Brazil.

Received: 1/16/2015 – Accepted: 9/20/2015

DOI: 10.1590/0101-60830000000042

Address correspondence to: Flávia L. Osório. Avenida dos Bandeirantes, 3900 – 14048-900 – Ribeirão Preto, SP, Brazil. Email: [email protected]


Background: Chronic pelvic pain (CPP) is a complex condition wich is associated with emotional factors, specially depression and anxiety. Objectives: To make a systematic review to provide a detailed summary of relevant literature on the association between CPP and different psychiatric disorders/symptoms. Methods: A systematic review of articles in the international literature published between 2003 and 2014 was performed in the electronic databases PubMed, PsycINFO, LILACS, and SciELO using the terms (chronic pelvic pain) AND (psychiatry OR psychiatric OR depression OR anxiety OR posttraumatic stress OR somatoform). The searches returned a total of 529 matches that were filtered according to predefined inclusion and exclusion criteria. A total of 18 articles were selected. Results: The investigations focused mainly on the assessment of depression and anxiety disorders/symptoms, with rather high rates (17-38.6%). Depression and anxiety symptoms were more prevalent among women with CPP compared to healthy groups. Comparisons between groups with CPP and with specific pathologies that also have pain as a symptom showed that depression indicators are more frequent in CPP. Depressive symptoms tend to be more common in CPP and have no particular association with pain itself, the core feature of CPP. Discussion: Other aspects of CPP seem to play a specific role in this association. Anxiety and other psychiatric disorders require further investigation so that their impact on CPP can be better understood.

Carvalho ACF et al. / Arch Clin Psychiatry. 2015;42(1):25-30

Keywords: Anxiety, comorbitidy, cronic pelvic pain, depression, psychiatric.


Chronic pelvic pain (CPP) is a common and disabling condition among women in reproductive age1,2 and is currently regarded as a public health problem3. International and Brazilian studies report prevalence rates of CPP ranging between 4% and 25.4%1,4-8. Although there is no complete agreement about the definition of CPP, the condition is characterized by the presence of continuous or intermittent pain in the lower abdomen (below the navel) and/or in the pelvis, persistent for at least six months, not exclusively associated with menstruation, sexual intercourse or neoplastic disease, severe enough to cause disability or functional impairment, and requiring clinical and/or surgical treatment9-13.

CPP is a complex condition of usually unknown etiology and influenced by or resulting from the interaction of various systems, including the gastrointestinal, urinary and genital tracts, and neurological and psychological aspects2. In up to 60% of cases, CPP is associated with emotional factors14, most commonly represented by depression and anxiety15. Researchers have been trying to identify the role played by emotional factors in the onset and maintenance of CPP, regarding such factors both as possible consequences of the chronic condition and also as etiological agents.

In this direction, evidence exists about the causal relationship between psychological factors and CPP, as women with the condition present significantly higher rates of psychiatric disorders as compared to control groups16-18. Other authors still report that negative mood and emotion can cause or increase pain19 and that the experience of pain, as a personal and subjective phenomenon, is probably affected by emotional states and, therefore, by psychosocial factors8.

Other investigators suggest exactly the opposite. To them, it is the context of chronic pain itself that favors feelings of frustration, preoccupation, anxiety, and depression8. Women with CPP have to deal with the loss of a healthy and active body and reach a state of dependence and disability that may be responsible for changes in affective, family, social, and sexual dynamics, thus having a negative impact on quality of life20. A study by Roth et al.21 investigated this hypothesis through the comparison of women with CPP and with other conditions involving chronic pain, especially migraine. Their findings showed that women with CPP were more dissatisfied with their marriage and capacity for sexual intercourse; however, no differences were found in regard to indicators of depression and anxiety or personality traits. These data suggest that, in general, when CPP patients present with psychological disturbances, these are likely to reflect the effects of chronic pain.

It should be noted, however, that many studies had inconclusive results because of the methodology or design adopted, and that the role played by emotional factors in the onset and maintenance of the condition remains largely unknown8,20,22,23.

Despite the large number of studies investigating the association between CPP and different psychological and psychiatric aspects, no systematic reviews or meta-analyses have been published to date dealing with this topic and contributing to expand the comprehension of this association.


The objective of this study was to perform a systematic literature review of articles published over the last 12 years in order to identify possible associations between CPP and different psychiatric disorders and/or symptoms.

Figure 1. Flowchart showing the procedure of article selection and inclusion/exclusion criteria.

Figure 1. Flowchart showing the procedure of article selection and inclusion/exclusion criteria.


This systematic review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Statement and the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions.

We made a systematic search for articles published between January 2003 and July 2014 indexed in the online databases PubMed, PsycINFO, LILACS, and SciELO using the search expression (chronic pelvic pain) AND (psychiatry OR psychiatric OR depression OR anxiety OR posttraumatic stress OR somatoform). The searches returned a total of 529 matches that were filtered according to predefined inclusion and exclusion criteria, as shown in figure 1.


A total of 18 articles were selected and independently examined in respect to their adequacy for inclusion in the review by two psychologists and mental health researchers. From these, five studies24-28 used an observational descriptive design and the remaining 138,20,21,29-38 used a case-control design. Most of the studies were conducted in the United States (n = 6) and Brazil (n = 5). Table 1 provides data on the studies’ design, country of origin, and main sample characteristics.

The clinical groups with CPP assessed in the studies included samples ranging between 12 and 713 subjects, with mean of 94.4 and median of 44. Subjects had a mean age of 35.6 years and large variations in education. Most of the studies established the presence of CPP through clinical diagnosis (n = 14) and presence of pain for at least six months (n = 12).

Table 1. Main characteristics of the samples in the studies reviewed

Table 1. Main characteristics of the samples in the studies reviewed

Table 2. Outcome variables and instruments used in the studies (N = 19; non-exclusive categories)

Table 2. Outcome variables and instruments used in the studies (N = 19; non-exclusive categories)

Control groups consisted of samples ranging between 20 and 1,131 subjects, with mean of 140.9 and median of 50. The mean age of participants in control groups was 35.3 years, equivalent to that of clinical groups, and similarly varied education. In general, control groups consisted of healthy women (n = 7) or people with other specific conditions involving pain (n = 8).

The most frequent inclusion criteria for the clinical groups were duration of pain symptoms8,20,21,24-27,29,31-36, which ranged from three to six months, and specificities related to the etiology of pain21,27,31-34,36,37, for example, pain resulting from pelvic adhesions. It is noteworthy that not all studies strictly followed the international criteria for the diagnosis of CPP, which require a minimum duration of six months for pain symptoms9-13.

Criteria for the inclusion in control groups consisted mainly of the absence of CPP20,21,27,29-36,38 and presence of other specific clinical conditions such as lower back pain and migraine27,29,30,34,36.

Exclusion criteria for the composition of CPP and control groups consisted mainly of the presence of other general (e.g.: interstitial cystitis, positive HIV, hypertension, diabetes) and/or gynecological conditions (e.g.: uterine fibroids and cysts) and pregnancy. It should be noted that nine studies24,26-28,29,31,33,34,36 described no exclusion criteria.

The main outcome measures assessed in the studies included (a) mood indicators (n = 17); (b) anxiety indicators (n = 9); and (c) somatization/dissociation indicators (n = 3). Table 2 shows the outcome measures and assessment instruments used in the studies reviewed.

As seen in table 2, a number of different instruments were used to assess outcome variables, most of which were self-rated. Mood indicators were mainly evaluated through the Beck Depression Inventory (BDI; n = 8; 44.4%), with only one study that reported the use of the Structured Clinical Interview for DSM-IV (SCID-IV), regarded as the gold standard for psychiatric diagnoses. In the assessment of anxiety indicators, only the Beck Anxiety Inventory (BAI) and the Hospital Anxiety and Depression Scale (HADS) were used in more than one study. For the assessment of somatization and dissociation indicators, the SCID-IV was the main instrument of choice (n = 2).

The main associations between CPP and psychiatric disorders/symptoms are shown in table 3.

Table 3. Main associations between CPP and psychiatric disorders and symptoms reported in the studies, with outcome variables as parameters

Table 3. Main associations between CPP and psychiatric disorders and symptoms reported in the studies, with outcome variables as parameters

The groups with CPP included in the studies had a high frequency of anxiety and depression symptoms, with respective prevalence rates of 38.6% and 29.5%. Relative to control groups, CPP subjects presented higher rates of depression (n = 7) and anxiety (n = 3), regardless of the instruments used in the assessments. Comparisons between groups with CPP and endometriosis concerning depression indicators showed that subjects with CPP had a higher frequency of mood symptoms.

When CPP groups were compared to control groups with chronic lower back pain, authors reported divergent findings related to depression rates29,30, despite the fact that the two studies making these comparisons had similar sampling procedures and used the same assessment instrument. Another investigation found equivalent rates of depression and anxiety in subjects with CPP and migraine21, and two others found no differences when comparing CPP groups with different etiologies27,37.

There are reports of significant positive associations between CPP and anxiety, depression and dissociation indicators, pain, and physical or sexual abuse24,25,28,29,38. On the other hand, negative associations have been found between CPP and depression, anxiety, sexual adjustment and quality of life31,36.

Finally, bipolar affective disorder (BAD) was more prevalent in a group with endometriosis36 and post-traumatic stress disorder (PTSD) was found in 31.3% of a group of subjects with CPP26. Dissociative and somatoform symptoms were highly prevalent in samples with CPP24,33.


This study systematically assessed the existence of associations between CPP and different psychiatric indicators/disorders through the exam of empirical articles published between 2003 and 2014.

Some remarks should be made concerning the methodological aspects of the studies included in this review, as they may affect the interpretation of the results presented. The first one refers to the study design adopted in the investigations, as 27.7% were descriptive studies. Also, there was great variability in the measures used, with a total of 18 different instruments, which hinders direct comparisons between their results. Most of the studies reviewed used screening instruments (83.4%) based on self-report. Only three studies used the SCID-IV, a structured, clinician-rated diagnostic interview regarded as the gold standard for the establishment of psychiatric diagnoses. We conclude, therefore, that most studies assessed the presence of symptoms, and not disorders.

The fact that most studies focused on the assessment of symptoms of depression and anxiety is also noteworthy. Other disorders as, for example, dysthymia and personality disorders, among others, were not contemplated, and attention to these conditions could be relevant for a better comprehension of psychic conditions associated with CPP.

Specifically in respect to the results of the studies reviewed, investigations using a case-control design enrolled healthy subjects and/or subjects with other pathological conditions associated or not with the presence of pain in their control groups. When assessing the prevalence rates reported in descriptive studies, depression and anxiety rates (29.5% ad 38.6%, respectively) are much higher than those found in the general population by a recent Brazilian epidemiological survey (9.4% and 19.9%, respectively)39. These rates are also higher than those reported by international epidemiological studies, as the one by Kessler et al.40 in which the lifetime rates of depression and anxiety were respectively 18.3% and 21.4% in an adult population. This large difference should be regarded with caution since the studies reviewed here assessed symptoms and not the presence of disorders as in epidemiological surveys. Still, however, the rates are high and should be considered as signs of increased difficulties.

Studies involving control groups formed by healthy subjects found that depression was more prevalent among women with CPP (n = 7), regardless of the instruments used to measure depression indicators. The same result was found by studies comparing anxiety in women with CPP and healthy women (n = 3), with the exception of the study by Kaya et al.32, where no differences were found.

Few studies included in the review (n = 5) compared groups with CPP and groups of subjects with specific pathologies that included pain as a symptom (namely, lower back and/or urogenital pain, migraine, and endometriosis) in an attempt to ascertain the influence of this variable. These investigations used common instruments and suggest that depression indicators tend to be more frequent in CPP groups, which opens the perspective to think of the existence of particular characteristics of CPP that associate with depression besides pain alone. In relation to anxiety, this type of comparative study is still scarce and do not allow for conclusions.

It should be noted that indicators of depression and anxiety va­ried between groups of CPP with different etiologies (endometriosis, myofascial pain, pelvic adhesions etc.), with inconclusive results from the different studies in the area.

Bipolar affective disorder was found in 44.4% of women with CPP associated with endometriosis, while no women with CPP without endometriosis presented this psychiatric condition. The fact that the rate of BAD in the general Brazilian population was estimated in 1.5%39 makes it difficult to explain the high frequency of this condition in the CPP group with associated endometriosis. However, if we consider CPP alone, the rate of BAD is close to that of the general population, or even smaller.

In CPP groups, the results available show associations of the condition with rates of depression and anxiety and increased presence of dissociation, pain, and physical and/or sexual abuse. On the other hand, reduced sexual adjustment and quality of life were negatively associated with these rates. These data raise the hypothesis of a possible chain reaction in which trauma, such as sexual abuse in childhood, could contribute to the etiology of CPP and also to the increase in depressive and dissociative experiences and somatic conditions25,28,29, in addition to having a negative impact on quality of life and sexual adjustment. The experience of these impairments and difficulties may feed back the chain, favoring experiences of anxiety and depression, which may also act as risk factors for the increase in experiences of pain, especially of somatic origin.

Along the same line, PTSD was observed in 31.3% of women with CPP, once again a high rate as compared with national39 and international40 data pointing to prevalence rates of 1.6% and 8%, respectively, in the general population. By relating these findings to the significant rates of dissociative symptoms and somatoform pain in CPP groups, we can again hypothesize that trauma might be a risk factor for the development of CPP. Only one study28, however, included logistic regression in its analysis. Future studies with this focus are therefore extremely necessary to provide evidence concerning the predictive role of trauma in the development of CPP.

In conclusion, depressive symptoms tend to be more present in CPP and this relationship does not seem to be specifically connected to pain, a core feature of CPP. Other factors particular to CPP seem to be implicated in this association. In this review, we found that traumatic experiences in childhood or adult life are some of the aspects that deserve attention. Also, anxiety and other specific disorders assessed, such as BAD, PTSD, and somatization disorder, require further investigation for the establishment of their role in CPP.

Directions for future research include: (a) greater methodological refinement involving other study designs, such as logistic regression, to investigate the impact of specific variables like early trauma; (b) detailed assessment of variables related to the duration and intensity of pain; and (c) use of diagnostic instruments with greater specificity and reliability.


This study received funding from National Council for Scientific and Technological Development (CNPq – Process No. 471441/2012-0).


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